高辉教授

  高辉，天津市特聘教授，曾入选教育部新世纪优秀人才支持计划、“天津市131创新型人才培养工程”第一层次人选、天津市创新人才推进计划中青年科技创新领军人才。电子邮件：1831968256@qq.com。致力于智能与功能高分子材料、生物医用材料的制备及其性能研究。

主持的科研项目：

1. 国家自然科学联合基金重点支持项目：基于结直肠癌内源性刺激的诊疗一体化超分子的构建（U20A200674），2021.01-2024.12，260万，主持；

2. 国家自然科学基金项目：具有抗核粒梭杆菌活性的超分子递送系统的构建及其靶向耐药结直肠癌的性能研究（22075209），2021.01-2024.12，63万，主持；

3. 国家自然科学基金项目：近红外聚集诱导发光和活性氧参与的高效基因载体的构建（21674080），2017.01-2020.12，66万，主持；

4. 国家自然科学基金项目：基于beta-环糊精的反相高分子胶束的构建及其在肽类药物传输中的应用（21374079），2013.01-2017.12，83万，主持；

5. 国家自然科学基金项目：含 beta-环糊精高分子的合成、反相胶束的构建及其在肽类药物控制释放中的应用（21244004），2013.01-2013.12，10万，主持；

6. 国家自然科学基金项目：含多氢键给体的高分子的合成及其作为基因载体的性能研究（21074092），2011.01-2013.12, 35万，主持；

7. 天津市自然科学基金重点项目：聚集诱导发光成像指导下的靶向光动力学与基因联合治疗（10JCYBJC26800）2018.04- 2021.03, 20万，主持；

8. 天津市自然科学基金：侧链降解型聚阳离子基因载体的合成及其性能研究（10JCYBJC26800），2010.10 - 2013.09，10万，主持；

9. 横向项目（天津市透明质酸应用研究企业重点实验室开放基金）：高效抗痤疮丙酸杆菌 HA 微针贴片的制备及其在痤疮治疗中的研究，2020.05- 2022.04，20万，主持；

10. 天津市“高等学校创新团队培养计划”（TD13-5020）,2018.04-2020.12，180万元，主持。

科研获奖：

天津市自然科学二等奖（2019ZR-2-006-R1）：高辉、杨英威、吕宏光、安金霞，超分子自组装在药物递送与生物成像中的应用基础研究

科研论文、专利：

先后在Angew. Chem. Int. Ed.，Adv. Func. Mater.，Chem. Mater., ACS Appl. Mater. Interfaces，Macromolecules等期刊发表论文近100余篇，SCI他引2500余次，H因子30。申请国内发明专利近10项，其中获授权国内发明专利5项。

近五年代表性论文：

1. X. Yan, F. Ma, Q. Chen, X. Gou, X. Li, L. Zhang, H. Gao*, Construction of size-transformable supramolecular nano-platform against drug-resistant colorectal cancer caused by Fusobacterium nucleatum, Chemical Engineering Journal, 2022, 450, 137605

2. W. J. Shi, J. X. An*, H. Tan, M. R. Jia, H. Gao*, A biomimetic non-antibiotic nanoplatform for low-temperature photothermal treatment of urinary tract infections caused by uropathogenic Escherichiacoli, Adv. Healthc. Mater., 2022,11，2101633.

3. Z. Luo, X. Yang, H. Tan, W. Shi, J. An, L. Yang, H. Gao*, Polymeric photothermal nanoplatform with the inhibition of aquaporin 3 for anti-metastasis therapy of breast cancer, Acta Biomaterialia, 2022, https://doi.org/10.1016/j.actbio.2022.09.026.

4. Q. Borjihan, H. X. Wu, A. Dong*, H. Gao*, Y. W. Yang*, AIEgens for Bacterial Imaging and Ablation, Adv. Healthc. Mater., 2021, 10(24):2100877.

5. H. Y. Liu, J. Yang, X. J. Yan, C. Q. Li, M. Elsabahy, L. Chen*, Y. W. Yang*, H. Gao*, A dendritic polyamidoamine supramolecular system composed of pillar[5]arene and azobenzene for targeting drug-resistant colon cancer, J. Mater. Chem. B., 2021, 9(46): 9594-9605.

6. H. G. Lu*, Y. D. Zheng, X. W. Zhao, L. J. Wang, S. Q. Ma, X. Q. Han, B. Xu, W. J. Tian, H. Gao*, Highly efficient far red/near-infrared solid fluorophores: aggregation-induced emission, intramolecular charge transfer, twisted molecular conformation, and bioimaging applications, Angew. Chem. Int. Ed., 2016, 128, 163-167. ESI高被引，他引191次。

7. Y. X. Zhang, H. Fu, S. Chen, B. Q. Liu, W. F. Sun, H. Gao*, Construction of an iridium(III)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging, Chem. Commun., 2020, 56, 762-765.

8. X.Jiang,Y. Yu, Y.Guan, T.Liu, C.Pang*, J.Ma, HGao*, Random and multiblock PBS copolyesters based on a rigid diol derived from naturally occurring   camphor: influence of chemical microstructure on thermal and mechanical   properties, ACS Sustainable Chem. Eng.,2020, 8, 3623-3636.

9. S. Z. Yan, S. Chen, X. B. Gou, J. Yang, J. X. An, X. Y. Jin, Y.-W. Yang*, L. Chen*, H. Gao*, Biodegradable supramolecular materials based on cationic polyaspartamides and pillar[5]arene for targeting gram-positive bacteria and mitigating antimicrobial resistance, Adv. Funct. Mater., 2019, 29, 1904683.

10. Y. Yu, C. C. Pang* , X. S. Jiang, Z. Y. Yang, J. B. Ma, H. Gao*, Copolycarbonates based on a bicyclic diol derived from citric acid and flexible 1,4-cyclohexanedimethanol: from synthesis to properties, ACS Macro Lett., 2019, 8, 454-459.

11. C. C. Pang*, X. S. Jiang, Y. Yu, L. Chen*, J. B. Ma, H. Gao*, Copolymerization of natural camphor-derived rigid diol with various dicarboxylic acids: Access to biobased polyesters with various properties, ACS Macro Lett., 2019, 8, 1442-1448.

12. N. Song, X.-Y. Lou, L. J. Ma, H. Gao*, Y.-W. Yang*, Supramolecular nanotheranostics based on pillarenes, Theranostics, 2019, 9, 3075-3093.

13. S. Chen, Q. X. Chen, Q. Y. Li, J. X. An, P. Sun, J. B. Ma, H. Gao*, Biodegradable synthetic antimicrobial with aggregation-induced emissive luminogens for temporal antibacterial activity and facile bacteria detection, Chem. Mater., 2018, 30, 1782-1790.

14. X. Liu, C. Pang*, J. Ma, H. Gao*, Random copolycarbonates based on a renewable bicyclic diol derived from citric acid, Macromolecules, 2017, 50 (20), 7949-7958.

15. S. Dong, Q. Chen, W. Li, Z. Jiang, J. Ma, H. Gao*, Dendritic catiomer with MOF motif for construction of safe and efficient gene delivery systems, J. Mater. Chem. B, 2017, 5, 8322-8329.

16. Q. Li, Y. Wu, H. Lu, X. Wu, S. Chen, N. Song, Y.-W. Yang*, H Gao*, Construction of supramolecular nanoassembly for responsive bacterial elimination and effective bacterial detection, ACS Appl. Mater. Interfaces, 2017, 9, 10180-10189.

17. Y. Guan, H. Lu* , W. Li, Y. Zheng, Z. Jiang, J. Zou, H Gao*, Near-infrared triggered upconversion polymeric nanoparticles based on aggregation-induced emission and mitochondria targeting for photodynamic cancer therapy, ACS Appl. Mater. Interfaces, 2017, 9, 26731-26739.

18. Y. Zheng, H. Lu*, Z. Jiang, Y. Guan, J. Zou, X. Wang, R. Cheng, H. Gao*, Low-power white light triggered AIE polymer nanoparticles with high ROS quantum yield for mitochondria-targeted and image-guided photodynamic therapy, J. Mater. Chem. B, 2017, 5, 6277-6281.

19. X. Q. Han, Q. X. Chen, H. G. Lu, P. Guo, W. Li, G. L. Wu, J. B. Ma, H. Gao*, Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA, Chem. Commun., 2016, 52, 3907-3910.

20. Y. Long, W. Gu, C. Pang, J. Ma, H. Gao*, Construction of coumarin-based cross-linked micelles with pH responsive hydrazone bond and tumor targeting moiety, J. Mater. Chem. B, 2016, 4, 1480-1488.

21. C. Fan, C. Pang*, X. Liu, J. Ma, H. Gao*, Self-curing furan-based elastic thermosets derived from citric acid, Green Chem., 2016, 18, 6320-6328.

22. Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao*, Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition, J. Mater. Chem. B, 2016, 4, 6350-6357.

23. X. Q. Han, Q. X. Chen, H. G. Lu, J. B. Ma, H. Gao*, Probe intracellular trafficking of polymeric DNA delivery vehicle by functionalization with aggregation-induced emissive tetraphenylethene derivative, ACS Appl. Mater. Interfaces, 2015, 7, 28494-28501.

24. Q. Li, S Xu, H. Zhou, X. Wang, B. Dong, H. Gao*, J. Tang*, Y. Yang*. pH and glutathione dual-responsive dynamic cross-linked supramolecular network on mesoporous silica nanoparticles for controlled anticancer drug release, ACS Appl. Mater. Interfaces, 2015, 7, 28656-28664.

25. X. Han, D. Liu, T. Wang, H. Lu, J. Ma, Q. Chen*, H. Gao*, Aggregation-induced-emissive molecule incorporated into polymeric nanoparticulate as FRET donor for observing doxorubicin delivery, ACS Appl. Mater. Interfaces, 2015, 7, 23760-23766.

26. P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H. Gao*, Dual functionalized amino poly(glycerol methacrylate) with guanidine and Schiff-base linked imidazole for enhanced gene transfection and minimized cytotoxicity, J. Mater. Chem. B, 2015, 3, 6911-6918.

27. Y. Wu, Y. Long, Q.-L. Li, S. Han, J. Ma, Y.-W. Yang*, H. Gao*, Layer-by-layer (LBL) self-assembled biohybrid nanomaterials for efficient antibacterial applications, ACS Appl. Mater. Interfaces, 2015, 7, 17255-17263.

28. W.-X. Gu, M. Zhu, N. Song, X. Du, Y.-W. Yang, H. Gao*,Reverse micelles based on biocompatible β-cyclodextrin conjugated polyethylene glycol block polylactide for protein delivery, J. Mater. Chem. B, 2015, 3, 316-322.