高辉教授

发布时间：2020-12-24文章来源:材料科学与工程学院浏览：36797




主要从事生物医用高分子材料研究，围绕纳米靶向抗菌/抗肿瘤材料和超分子响应性材料、肠道菌群调控等开展理论和应用研究。

主持国家重点研发计划1项，国家自然科学基金联合基金重点支持项目等国家级项目6项、省部级项目6项，先后在Angew. Chem. Int. Ed., Adv. Func. Mater., Nano Today, Macromolecules等期刊发表论文100余篇，引用4000余次，获得授权发明专利9项。

联系方式：huigao@tiangong.edu.cn

   人才称号：

  1. 2010年入选日本学术振兴会（JSPS）特邀访问教授（长期）

  2. 2011年入选教育部新世纪优秀人才支持计划

  3. 2012年入选天津市高校“中青年骨干创新人才培养计划”

  4. 2015年入选“天津市131创新型人才培养工程”第一层次人选

  5. 2017年入选天津市“学科领军人才培养计划”

  6. 2017年入选天津市“特聘教授”

  7. 2019年入选天津市创新人才推进计划

  8. 2022年获得天津市“三八”红旗手称号


承担课题：

  主持包括国家重点研发计划、国家自然科学基金联合基金项目在内的国家级项目7项。

  1. 国家重点研发计划政府间国际科技创新合作重点专项：靶向清除结直肠癌相关Fn及其生物被膜重塑肿瘤免疫微环境（2024YFE0104000），2024.07-2027.06，200万，主持

  2. 国家自然科学基金联合基金项目：基于结直肠癌内源性刺激的诊疗一体化超分子的构建（U20A20260），2021.01-2024.12，260万，主持

  3. 国家自然科学基金面上项目：具有抗核粒梭杆菌活性的超分子递送系统的构建及其靶向耐药结直肠癌的性能研究（22075209），2021.01-2024.12，63万，主持

  4. 国家自然科学基金面上项目：近红外聚集诱导发光和活性氧参与的高效基因载体的构建（21674080），2017.01-2020.12，66万，主持

  5. 国家自然科学基金面上项目：基于beta-环糊精的反相高分子胶束的构建及其在肽类药物传输中的应用（21374079），2013.01-2017.12，83万，主持

  6. 国家自然科学基金主任基金：含 beta-环糊精高分子的合成、反相胶束的构建及其在肽类药物控制释放中的应用（21244004），2013.01-2013.12，10万，主持

  7. 国家自然科学基金面上项目：含多氢键给体的高分子的合成及其作为基因载体的性能研究（21074092），2011.01-2013.12, 35万，主持

  8. 天津市自然科学基金重点项目：聚集诱导发光成像指导下的靶向光动力学与基因联合治疗（18JCZDJC37700）2018.04-2021.03, 20万，主持

  9. 天津市自然科学基金重点项目：聚集诱导发光成像指导下的靶向光动力学与基因联合治疗（18JCZDJC37700）2018.04-2021.03, 20万，主持

  10. 天津市自然科学基金面上项目：侧链降解型聚阳离子基因载体的合成及其性能研究（10JCYBJC26800），2010.10 -2013.09，10万，主持

  11. 天津市“高等学校创新团队培养计划”（TD13-5020），2018.04-2020.12，180万元，主持。

  12. 973计划前期专项：新型生物降解高分子纳米材料的合成及其环境响应性能（2009CB626612），2009.04-11.08，55万元，是天津理工大学方负责人（20万）

  13. 天津市透明质酸应用研究企业重点实验室开放基金项目，高效抗痤疮丙酸杆菌 HA 微针贴片的制备及其在痤疮治疗中的研究（KTRDHA-Z201901） 2020.05-2023.05，20万，主持

  14. 天津工业大学沧州研究院项目，面向创面修复的多功能干态凝胶纳米纤维膜贴片，2025.01-2026.06，100万，主持


文章情况：

  以第一作者或者通讯作者在Angew. Chem. Int. Ed. , Adv. Func. Mater. , Chem. Mater. , Nano Today, Macromolecules等期刊发表论文100余篇，引用4000余次，H因子37。其中中科院二区以上论文80余篇；一区论文42篇，如下：

  1. X. Li, Y. Wu, M. Wu, J. Gao, Y. Zhang, Y. Zhang, T. Wu,H. Gao*, Pure Zwitterionic hydrogel with mechanical robustness and dynamic tunability enabled by synergistic non-covalent interactions, Adv. Funct. Mater., 2024, DOI: 10.1002/adfm.202409594.

  2. T. Wu, D. Jin, M. Wu, Y. Xin, H. Liu, N. Li, F. Ma, Y. Yu*, B. Wang, J. Zhao, J. Zhang, X. Qu,H. Gao*, Blocking Fusobacterium nucleatum-host cell interactions with responsive supramolecular GalNAc-derived nanoplatform for enhanced chemotherapy in colorectal cancer, Nano Today, 2024, 56, 102288.

  3. X. Li, J. Niu, L. Deng, Y. Yu, L. Zhang, Q. Chen, J. Zhao, B. Wang,H. Gao*, Amphiphilic polymeric nanodrug integrated with superparamagnetic iron oxide nanoparticles for synergistic antibacterial and antitumor therapy of colorectal cancer, Acta. Biomater., 2024, 173, 432-441.

  4. N. Li, Y. Yu, Q. Chen, J. Niu, C. Gao, X. Qu, J. Zhang,H. Gao*, A gene delivery system with autophagy blockade for enhanced anti-angiogenic therapy against Fusobacterium nucleatum-associated colorectal cancer, Acta. Biomater., 2024, 183, 278-291.

  5. H. Liu, Y. Yu, A. Dong, M. Elsabahy, Y. Yang*, H. Gao*, Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges, Exploration, 2023, 4, 20230092.

  6. Y. Xin, Y. Yu, M. Su, X. Li, M. Elsabahy,H. Gao*, In situ-activated photothermal nanoplatform for on-demand NO gas delivery and enhanced colorectal cancer treatment, J. Controlled Release, 2023, 359, 69-84.

  7. X. Yan, F. Ma, Q. Chen, X. Gou, X. Li, L. Zhang, H. Gao*, Construction of size-transformable supramolecular nano-platform against drug-resistant colorectal cancer caused by Fusobacterium nucleatum, Chem. Eng. J., 2022, 450, 137605.

  8. Z. Luo, X. Yang, H. Tan, W. Shi, J. An*, L. Yang*,H. Gao*, Polymeric photothermal nanoplatform with the inhibition of aquaporin 3 for anti-metastasis therapy of breast cancer, Acta. Biomater., 2022, 153, 505-517.

  9. X. S. Jiang, Y. Yu, Y. Z. Guan, T. Liu, C. C. Pang*, J. B. Ma, H. Gao*, Random and Multiblock PBS Copolyesters Based on a Rigid Diol Derived from Naturally Occurring Camphor: Influence of Chemical Microstructure on Thermal and Mechanical Properties, ACS Sustain. Chem. Eng., 2020, 8(9): 3626-3636.

  10.  Y. X. Zhang, H. Fu, D.-E. Liu, J. X. An*, H. Gao*, Construction of biocompatible bovine serum albumin nanoparticles composed of nano graphene oxide and AIEgen for dual-mode  phototherapy bacteriostatic and bacterial tracking, J. Nanobiotechnol., 2019, 17:104.

  11. S. Z. Yan, S. Chen, X. B. Gou, J. Yang, J. X. An, X. Y. Jin, Y.-W. Yang*, L. Chen*, H. Gao*, Biodegradable supramolecular materials based on cationic polyaspartamides and pillar[5]arene for targeting gram-positive bacteria and mitigating antimicrobial resistance, Adv. Funct. Mater., 2019, 29, 1904683.

  12. Y. Yu, C. C. Pang,* X. S. Jiang, Z. Y. Yang, J. B. Ma, H. Gao*, Copolycarbonates based on a bicyclic diol derived from citric acid and flexible 1,4-cyclohexanedimethanol: From synthesis to properties, ACS Macro Lett., 2019, 8, 454-459.

  13.  C. C. Pang,* X. S. Jiang, Y. Yu, L. Chen,* J. B. Ma, H. Gao*, Copolymerization of natural camphor-derived rigid diol with various dicarboxylic acids: Access to biobased polyesters with various properties, ACS Macro Lett., 2019, 8,1442-1448.

  14. N. Song, X.-Y. Lou, L. J. Ma, H. Gao*, Y.-W. Yang*, Supramolecular nanotheranostics based on pillarenes, Theranostics, 2019, 9, 3075-3093.

  15. C. C. Pang*, X. S. Jiang, Y. Yu, X. H. Liu, J. Y. Lian, J. B. Ma, H. Gao*, Sustainable polycarbonates from a citric acid-based rigid diol and recycled BPA-PC: from synthesis to properties, ACS Sustainable Chem. Eng., 2018, 6, 17059-17067.

  16. X. Liu, C. Pang*, J. Ma, H. Gao*, Random copolycarbonates based on a renewable bicyclic diol derived from citric acid,Macromolecules, 2017, 50 (20), 7949-7958.

  17. S. Dong, Q. Chen, W. Li, Z. Jiang, J. Ma, H. Gao*, Dendritic catiomer with MOF motif for construction of safe and efficient gene delivery systems, J. Mater. Chem. B, 2017, 5, 8322-8329.

  18. Q. Li, Y. Wu, H. Lu, X. Wu, S. Chen, N. Song, Y.-W. Yang*, H Gao*, Construction of supramolecular nanoassembly for responsive bacterial elimination and effective bacterial detection, ACS Appl. Mater. Interfaces, 2017, 9, 10180-10189.

  19. Y. Guan, H. Lu* , W. Li, Y. Zheng, Z. Jiang, J. Zou, H Gao*, Near-infrared triggered upconversion polymeric nanoparticles based on aggregation-induced emission and mitochondria targeting for photodynamic cancer therapy, ACS Appl. Mater. Interfaces, 2017, 9, 26731-26739.

  20. Y Zheng, H Lu,* Z Jiang, Y Guan, J Zou, X Wang, R Cheng, H Gao*, Low-power white light triggered AIE polymer nanoparticles with high ROS quantum yield for mitochondria-targeted and image-guided photodynamic therapy, J. Mater. Chem. B, 2017, 5, 6277-6281.

  21.  X. Q. Han, Q. X. Chen, H. G. Lu, P. Guo, W. Li, G. L. Wu, J. B. Ma, H.Gao*, Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA, Chem. Commun., 2016, 52, 3907-3910.

  22.  H. Lu*, Y. Zheng, X. Zhao, L. Wang, S. Ma, X. Han, B. Xu, W. Tian, H. Gao*,Highly efficient farRed/Near-infrared solid fluorophores: aggregation-induced emission, intramolecular charge transfer, twisted molecular conformation, and bioimaging application. Angew. Chem. Int. Ed., 2016, 55, 155 -159.

  23.  Y. Long, W. Gu, C. Pang, J. Ma, H. Gao*,Construction of coumarin-based cross-linked micelles with pH responsive hydrazone bond and tumor targeting moiety, J. Mater. Chem.B, 2016, 4, 1480-1488.

  24.  C. Fan, C. Pang,* X. Liu, J. Ma, H. Gao*, Self-curing furan-based elastic thermosets derived from citric acid, Green Chem. 2016, 18, 6320-6328.

  25.  Y. Wu, Q. Chen, Q. Li, H. Lu, X. Wu, J. Ma, H. Gao*, Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition, J. Mater. Chem. B, 2016, 4, 6350-635.

  26. X. Q. Han, Q. X. Chen, H. G. Lu, J. B. Ma, H. Gao*, Probe intracellular trafficking of polymeric DNA delivery vehicle by functionalization with aggregation-induced emissive tetraphenylethene derivative, ACS Appl. Mater. Inter.,2015, 7, 28494-28501.

  27. Q. Li, S Xu, H. Zhou, X. Wang, B. Dong, H. Gao*, J. Tang*, Y. Yang*. pH and glutathione dual-responsive dynamic cross-linked supramolecular network on mesoporous silica nanoparticles for controlled anticancer drug release, ACS Appl. Mater. Interfaces,2015, 7, 28656-28664.

  28. X. Han, D. Liu, T. Wang, H. Lu, J. Ma, Q. Chen*, H. Gao*, Aggregation-induced-emissive molecule incorporated into polymeric nanoparticulate as FRET donor for observing doxorubicin delivery. ACS Appl. Mater. Interfaces, 2015, 7 (42), 23760-23766.

  29. P. Guo, W. Gu, Q. Chen, H. Lu, X. Han, W. Li, H. Gao*, Dual functionalized amino poly(glycerol methacrylate) with guanidine and Schiff-base linked imidazole for enhanced gene transfection and minimized cytotoxicity. J. Mater. Chem., B, 2015, 3, 6911-6918.

  30. Y. Wu, Y. Long, Q.-L. Li, S. Han, J. Ma, Y.-W. Yang*, H. Gao*,Layer-by-layer (LBL) self-assembled biohybrid nanomaterials for efficient antibacterial applications, ACS Appl. Mater. Interfaces,2015, 7, 17255-17263.

  31. H. Gao, H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata*, K. Kataoka*, Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity. Chem. Commun.,2015, 51, 3158-3161.

  32. W.-X. Gu, Q.-L. Li, H. Lu, L. Fang, Q. Chen, Y.-W. Yang*, H. Gao*, Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery. Chem. Commun.,2015, 51, 4715-4718.

  33. W.-X. Gu, M. Zhu, N. Song, X. Du, Y.-W. Yang, H. Gao*,Reverse micelles based on biocompatible β-cyclodextrin conjugated polyethylene glycol block polylactide for protein delivery.J. Mater. Chem. B,2015, 3, 316-322.

  34. Q-L Li,W Gu, H. Gao*, Yang, Y.-W*, Self-assembly and applications of poly(glycidyl methacrylate)s and their derivatives. Chem. Commun., 2014, 50, 13201-13215.

  35. Q-L Li,Y. Sun,Y -L Sun, J. Wen, Y. Zhou, Q. Bing, L. Isaacs, Y Jin, H. Gao*, Y-W Yang*,Mesoporous silica nanoparticles coated by layer-by-layer self-assembly using cucurbit[7]uril for in vitro and in vivo anticancer drug release.Chem Mater., 2014, 26, 6418-6431.

  36. H. Gao, X. Y. Lu, Y. N. Ma, Y. W. Yang, J. F. Li, G. L. Wu, Y. N. Wang, Y. G. Fan, J. B. Ma*, Amino poly(glycerol methacrylate)s for oligonucleic acid delivery with enhanced transfection efficiency and low cytotoxicity,Soft Matter, 2011, 7, 9239-9247.

  37. H. G. Fu, H. Gao*, G. L. Wu, Y. N. Wang, Y. G. Fan, J. B. Ma. Preparation and tunable temperature-sensitivity of biodegradable polyurethane nanoassemblies from diisocyanate and poly(ethylene Glycol), Soft Matter, 2011, 7, 3546-3552.

  38. H. Gao, M. Elsabahy, E.V. Giger, D.K. Li,R.E. Prud’homme, J.C. Leroux, Aminated linear and star-shape poly(glycerol methacrylate)s: synthesis and self-assembling properties, Biomacromolecules, 2010, 11, 889-895.

  39. H. Gao, M.-C. Jones, J. Chen, Y.R. Liang, R. E. Prud’homme, J.-C. Leroux, Hydrophilic nanoreservoirs embedded into polymeric nanoparticles - An approach to compatibilize polar molecules with hydrophobic matrices. Chem. Mater.,2008, 20, 4191-4193.

  40. H. Gao, M.-C. Jones, J. Chen, R. E. Prud’homme, J.-C. Leroux, Core cross-linked reverse polymeric micelles. Chem. Mater., 2008, 20, 3063-3067.

  41. H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates of poly(DL-lactic acid) with ethylenediamino or diethylenetriamino bridged bis(beta-cyclodextrin)s and their nanoparticles as protein delivery systems. J. controlled release, 2006, 112, 301-311.

  42. H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Synthesis of a biodegradable tadpole-shaped polymer via the coupling reaction of polylactide onto mono(6-(2-aminoethyl) amino-6-deoxy)- β -cyclodextrin and its properties as the new carrier of protein delivery system. J. controlled release, 2005, 107, 158-173.


专利情况：

获得授权发明专利9项。

  1. 高辉；辛友涛；马艳梅。一种将抗菌和抗肿瘤结合实现结肠癌的诊疗一体化纳米粒子的制备方法，ZL202111200594.7

  2. 高辉；马艳梅；黄文钊。一种靶向细菌和细胞的抗耐药结直肠癌纳米药物载体的制备方法，ZL202111200593.2

  3. 高辉；孙现科；马建标。具有pH响应性的生物降解聚氨酯材料的制备方法，ZL201010511225.5

  4. 高辉；顾文星；马亚男；陆学友；马建标。一种具有pH响应性聚甲基丙烯酸甘油酯的制备方法，ZL201110282730.1

  5. 高辉；朱明冉。一种基于油相的两亲性高分子反相微乳的制备方法，ZL201310454392.4

  6. 高辉；顾文星；王立志；郭盼。一种准嵌段共聚物反相高分子胶束的制备方法，ZL201310420819.9

  7. 高辉；李巧英；吴元昊；陈帅。具有可控的抑菌活性和细菌检测的自组装超分子纳米材料的制备方法，ZL201710095911.0

  8. 吕宏光；高辉；石季；郑雅丹。一种高聚集荧光发射的荧光标记分子及其制备方法，ZL201510246913.6

  9. 高辉；朱华杰；安金霞；黄泳糠 具有活性氧和pH双重响应性及电荷反转特性的智能基因载体的制备方法,ZL201811047757.0

  10. 李晓晖；高嘉伟；高辉。一种自聚集诱导聚合硫辛酸基两性离子水凝胶及其制备方法,CN202410645432.1

  11. 高辉；吴宇；李晓晖。一种脲基磺基甜菜碱两性离子水凝胶及其制备方法，CN202310312301.7


获奖情况：

  1. 高辉、杨英威、吕宏光、安金霞，超分子自组装在药物递送与生物成像中的应用基础研究，天津市自然科学二等奖（2019年）

  2. 马建标、王亦农、王小红、高辉、范云鸽，天然生物高分子的修饰及其生物医学性能（2010ZR-3-006）天津市自然科学三等奖（2010年）


Copyright © 2017, http://clxy.tiangong.edu.cn/, All Rights Reserved

版权所有：天津工业大学 材料科学与工程学院

地址：天津市西青区宾水西道399号 邮编：300387