个人简介:余云健,博士,湖北省阳新县人。2020年于南开大学获得高分子化学与物理专业理学博士学位(导师:张新歌教授),同年进入武汉大学化学学院开展博士后研究(合作导师:张先正教授)。2023年2月进入天津工业大学材料学院高辉教授团队,致力于设计、开发新型生物医用高分子材料,目前已在Adv. Mater., Adv. Sci., Biomaterials, J. Control. Release, Bioact. Mater., Chem. Mater., Chem. Commun.等国际著名期刊发表 SCI 论文36篇,其中第一或通讯作者14篇,他引1000余次。
联系方式:
E-mail:yuyunjian@tiangong.edu.cn;
地址:天津市西青区宾水西道399号材料科学与工程学院6B324;邮编:300387。
研究方向:
1. 生物活性高分子材料的创制与应用探索;
2. 靶向药物递送用于高效清除胞内耐药细菌;
3. 肠道菌群精准调控助力微生物相关肿瘤等疾病诊疗。
科研项目:
1. 国家自然科学基金委员会,青年项目,52303155,自适应铁基纳米酶清除肿瘤胞内菌重塑结直肠癌免疫微环境,2024-01-01至2026-12-31, 30万, 主持
2. 国家自然科学基金委员会,面上项目,51673102,抗肿瘤纳米药物载体构建及其免疫逃逸抑制巨噬细胞吞噬机制,2017-01-01至2020-12-31, 64万, 已结题,参与(8/10)
3. 国家自然科学基金面上项目,基于细菌生物被膜结构特征构建生物学自适应抗菌材料研究,项目编号21774062, 2018-01-01至2021-12-31, 62万, 已结题,参与(6/7)
4. 国家自然科学基金面上项目,硼酸功能化大分子介导β-内酰胺酶水解活性及其免疫调控效应研究,项目编号21975133, 2020-01-01至2023-12-31, 65万, 在研,参与(3/10)
5. 天津大学,技术开发项目,低表面能海洋防污涂层的研制,2023-05-31至2024-05-31, 8万,在研,参与(5/7)
近5年的代表性论著:
1. T. Wu, D. Jin, M. Wu, Y. Xin, H. Liu, N. Li, F. Ma, Yunjian Yu*, B. Wang, J. Zhao, J. Zhang, X. Qu, H. Gao*. Blocking Fusobacterium nucleatum-host cell interactions with responsive supramolecular GalNAc-derived nanoplatform for enhanced chemotherapy in colorectal cancer. Nano Today, 2024, 56, 102288.
2. N. Li#, Yunjian Yu#, Q. Chen, J. Niu, C. Gao, X. Qu, J. Zhang, H. Gao*. A gene delivery system with autophagy blockade for enhanced anti-angiogenic therapy against Fusobacterium nucleatum-associated colorectal cancer. Acta Biomaterialia, 2024, 183, 278-291. (#并列一作)
3.H. Liu#, Yunjian Yu#, A. Dong, Y.-W. Yang*, and H. Gao*.Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: systematic review, improvements and future challenges. Exploration, 2024, 4: 20230092. (#并列一作)
4.Y. Xin#, Yunjian Yu#, M. Su, X. Li, M. Elsabahy, H. Gao*; In situ-activated photothermal nanoplatform for on-demand NO gas delivery and enhanced colorectal cancer treatment. Journal of Controlled Release, 2023, 359, 69-84. (#并列一作)
5.Yunjian Yu, J.-H. Yan, Q.-W. Chen, J.-Y. Qiao, S.-Y. Peng, H. Cheng, M. Chen*, X.-Z. Zhang*. Polymeric nano-system for macrophage reprogramming and intracellular MRSA eradication. Journal of Controlled Release, 2023, 353, 591-610.
6. Yunjian Yu, J. Li, B. Song, Z. Ma, Y. Zhang, H. Sun, X. Wei, Y. Bai, X. Lu, P. Zhang*, X. Zhang*. Polymeric PD-L1 blockade nanoparticles for cancer photothermal-immunotherapy.Biomaterials, 2022, 280, 121312.
7.Yunjian Yu, J. Li, Y. Zhang, Z. Ma, H. Sun, X. Wei, Y. Bai, Z. Wu, X. Zhang*. A bioinspired hierarchical nanoplatform targeting and responding to intracellular pathogens to eradicate parasitic infections. Biomaterials, 2022, 280, 121309.
8. Yunjian Yu, Y. Zhang, X. Wei, Z. Ma, H. Sun, J. Li, Y. Bai, X. Zhang*. NIR-activated nanosystems with self-modulated bacteria targeting for enhanced biofilm eradication and caries prevention. Bioactive Materials, 2022, 13,269-285.
9. Yunjian Yu, T. Zhang, X. Dai, X. Dai, X. Wei, X. Zhang* and C. Li. Therapeutic nanoplatforms with bacteria-specific activation for directional transport of antibiotics. Chemical Communications, 2018, 54, 12754-12757.
10. Yunjian Yu, X. Dai, X. Wei, X. Dai, C. Yu, X. Duan, X. Zhang* and C. Li.Synthetic fluorescent nanoplatform based on benzoxaborole for broad-spectrum inhibition of bacterial adhesion to host cells. Chemistry of Materials, 2018, 30, 8795-8803.
11.Yunjian Yu, L. Mei, Y. Shi, X. Zhang, K. Cheng, F. Cao, L. Zhang, X. Jia, X. Li, Z. Xu. Ag-conjugated graphene quantum dots with blue light-enhanced singlet oxygen generation for ternary-mode highly-efficient antimicrobial therapy. Journal of Materials Chemistry B,2020, 8, 1371l-1382.
12. Y. Zhang#, Yunjian Yu#, G. Li, H. Meng, X. Zhang, L. Dong, Z, Wu, and L. Li. A bioadhesive nanoplatform enhances the permeantion of drugs used to treat diabetic macular edema. ACS Applied Bio Materials, 2020, 3, 2314-2324. (#并列一作)
13. Y. Zhang#, Yunjian Yu#, X. Zhang. Epithelium-penetrable nanoplatform with enhanced antibiotic internalization for management of bacterial keratitis. Biomacromolecules, 2021, 22, 2020-2032. (#并列一作)
14. Y. Zhang#, Yunjian Yu#, X. Zhang. Bioadhesive glycosylated nanoformulations for extended trans-corneal drug delivery to suppress corneal neovascularization. Journal of Materials Chemistry B, 2021, 9, 4190-4200. (#并列一作)
欢迎心理健康、对科学热忱、吃苦耐劳、具有高分子化学背景的优秀考生加入,共谋盛举。